Derivatives of dihydropyridine-3,5-dicarboxylate and...

Details Derivatives of dihydropyridine-3,5-dicarboxylate and... Derivatives of dihydropyridine-3,5-dicarboxylate and...

C - Chemistry, Metallurgy

07

D

167/211, 260/242

C07D 211/90 (2006.01) C07D 309/32 (2006.01) C07D 401/04 (2006.01)

Patent

CA 1239401

Abtract New compounds, processes for their preparation and their use as medicanments Compounds of the formula Image in which R is an optionally substituted aryl or heterocyclic radical, R1 is a hydrocarbon radical which is optionally inter- rupted by 1 oxygen atom in the chain, and/or which is optionally substituted, R4 is an aliphatic hydrocarbon radical having 7 to 14 carbon atoms, which is optionally interrupted by one oxygen atom and/or which is optionally substituted, R2 and R3 each independently is hydrogen, an alkyl radical, an aryl radical or an aralkyl radical, or, for the case where one of the substituents R2 or R3 has the above-mentioned meaning, the other is hydroxymethyl, acetoxymethyl or amino, and X is N-R5, wherein R5 is hydrogen, an alkyl radical which is optionally interrupted by an oxygen atom, a morpholinoalkyl radical, an aryl radical or an aralkyl radical or X is an oxygen atom, when one of the radicals R2 or R3 denotes an amino group, or pharmaceutically acceptable acid addition salts thereof, exhibit hypotensive activity.

423079

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