Process for the preparation of optically active secondary...

Details Process for the preparation of optically active secondary... Process for the preparation of optically active secondary...

C - Chemistry, Metallurgy

07

C

260/320, 260/600

C07C 209/00 (2006.01) C07C 209/52 (2006.01) C07C 211/48 (2006.01) C07D 333/36 (2006.01)

Patent

CA 1301176

- ? - 6-16034/+ Process for the preparation of optically active secondary arylamines Abstract Asymmetric hydrogenation of prochiral,N-arylketimines to give optically active secondary amines at a temperature of -20 to 80°C, a hydrogen pressure of 105 to 6.106 Pa with the addition of catalytic amounts of an iridium compound of the formula III or IIIa [XIrYZ] (III) or [XIrY]?A? (IIIa) in which X is two olefin ligands or one diene ligand, Y is a chiral diphosphine, the secondary phosphine groups of which are linked by 2-4 C atoms and which, together with the Ir atom, forms a 5-, 6- or 7-ring, or Y is a chiral diphosphin- ite, the phosphinite groups of which are linked via 2 C atoms and which together with the Ir atom forms a 7-ring, Z is Cl, Br or I and A? is the anion of an oxygen acid or complex acid, and if appropriate with the addition of an ammonium or alkali metal chloride, bromide or iodide.

543518

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