C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/272
C07D 455/00 (2006.01) A61K 31/395 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) C07D 455/02 (2006.01) C07D 455/03 (2006.01) C07D 471/00 (2006.01) C07D 471/16 (2006.01) C07D 471/18 (2006.01)
Patent
CA 1325634
ABSTRACT OF THE DISCLOSURE The present invention is directed to a group of esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-ones and related compounds. The compounds are prepared from the appropriate carboxylic acids and alcohols by standard procedures or, where steric factors are significant, a new process which makes use of heavy metal salts of super acids can be used. The compounds involved are useful in the treatment of migraine and similar disorders and in cytotoxic drug-induced vomiting.
597287
Merrell Dow Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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