C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/207, 260/327
C07D 311/58 (2006.01) C07D 311/16 (2006.01) C07D 311/64 (2006.01) C07D 335/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 493/04 (2006.01)
Patent
CA 1338894
The present invention includes compounds represented by the formula: Image wherein X is O or S; R1 and R2 are independently selected from the group consisting of hydrogen, hydroxy, halo, loweralkoxy, thioalkoxy and loweralkyl; or R1 and R2 taken together can form a methylenedioxy or ethylenedioxy bridge; R3 is loweralkyl; R4 is selected from Image and Image wherein Y is O or S, R6 is hydrogen, methoxy or halo and m is 0 or 1; R5 is hydrogen, loweralkyl, phenyl or substituted phenyl wherein the phenyl ring is substituted with one, two or three substituents independently selected from loweralkyl, halo, hydroxy, loweralkoxy, amino and thioalkoxy; and R8 is hydrogen or R3 and R8 taken together form a pyrrolidine ring; or a pharmaceutically acceptable salt thereof. The compounds of the invention are useful in the treatment of depression, metabolic disorders, glaucoma, migraine and hypertension.
588247
Arendsen David Lloyd
de Bernardis John Francis
Zelle Robert Edward
Abbott Laboratories
Goudreau Gage Dubuc
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