Substituted dibenzodiazepinones, processes for the...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/06 (2006.01) C07D 243/38 (2006.01) C07D 401/06 (2006.01) C07D 451/02 (2006.01) C07F 9/645 (2006.01)

Patent

CA 1189507

ABSTRACT OF THE DISCLOSURE Chemical Compounds Compounds of general formula I Image (I) (wherein R1 represents a hydrogen or a chlorine atom and R represents a (1-methyl-4-piperidinyl)methyl, (1-methyl-1,2,5,6-tetrahydro-4-pyridinyl)methyl, 1- methyl-1,2,5,6-tetrahydro-4-pyridinyl, (1-methyl-4- piperidinylidene)methyl, (2,3-dehydro-8-methyl-8-aza- bicyclo[3.2.1]oct-3-yl)-methyl, (8-methyl-8-aza-bicyclo- [3.2.1]oct-3-ylidene)-methyl or endo- or exo-(8- methyl-8-azabicyclo[3.2.1]oct-3-yl)methyl group, each group being optionally substituted by one or two further methyl groups in the heterocyclic ring), and optical isomers thereof and acid addition salts of the afore- mentioned compounds. Process for preparing the new compounds and pharmaceutical compositions containing them are also described. The compounds of formula I and their acid addition salts have an antiulcerative effect and an inhibitory effect on the secretion of gastric acid without the side effects which normally occur with substances having an anticholinergic activity, such as dryness of the mouth and mydriasis.

420920

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