Derivatives of cis, endo-2-azabicyclo-[3.3.0]-...

Details Derivatives of cis, endo-2-azabicyclo-[3.3.0]-... Derivatives of cis, endo-2-azabicyclo-[3.3.0]-...

C - Chemistry, Metallurgy

07

D

260/317, 260/306

C07D 209/52 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1187087

Abstract of the disclosure: Compounds of the formula I (I) Image in which the carboxyl group on carbon atom 3 is orienta- ted in the endo-position relative to the bicyclic ring system of cis-configuration, and in which R1 denotes hydro- gen, allyl, vinyl or a side-chain of a naturally occurring ?-aminoacid, which may be protected, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl and Z denotes hydrogen, or Y and Z together denote oxygen, and X denotes alkyl, alkenyl or cycloalkyl, or aryl which is optionally mono-, di- or tri-substituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, di- alkylamino or methylenedioxy, or denotes indol-3-yl, a process for their preparation, agents containing these com- pounds and their use. Compounds of the formula I have a long-lasting intense hypotensive action.

414858

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