Pharmacologically active compounds

Details Pharmacologically active compounds Pharmacologically active compounds

C - Chemistry, Metallurgy

12

N

195/35, 167/103.

C12N 9/99 (2006.01) C07K 14/315 (2006.01) C12N 9/72 (2006.01) C12N 9/96 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1192514

ABSTRACT A derivative of streptokinase-human plasminogen activator complex, in which the active catalytic site essential for fibrinolytic activity is blocked by a 2- or 4-aminobenzoyl group, is useful in treating venous thrombosis. The blocking group is removable by hydrolysis such that the first order rate is in the range 0.7 x 10-5sec-1 to 2.5 x 10-5sec-1 in isotonic aqueous media at pH 7.4 at 37°C.

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