Pharmaceutical benzoheterocyclylcarboxamide derivatives

Details Pharmaceutical benzoheterocyclylcarboxamide derivatives Pharmaceutical benzoheterocyclylcarboxamide derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/300

C07D 209/22 (2006.01) C07D 209/18 (2006.01) C07D 231/56 (2006.01) C07D 235/04 (2006.01) C07D 241/42 (2006.01) C07D 249/18 (2006.01) C07D 265/36 (2006.01) C07D 333/60 (2006.01) C07D 403/10 (2006.01)

Patent

CA 1336192

This invention provides a series of novel heterocyclic amides of Formula I Image I in which the group >X-Y-z< is selected from >C=CH-N<, >C=N-N<, >N-(CH2)-N<, >CH-CH2-N< and >N-N=C< and the other radicals have meanings defined, for example, wherein: A is a direct link when Z is nitrogen & A is oxygen when Z is carbon: R1 is an optionally substituted alkyl group; Ra is hydrogen or methyl: Rc is selected from a group consisting of hydrogen and alkoxy; Rd is hydrogen, cycloalkyl, cycloalkyl-alkyl or alkyl optionally containing one or two double or triple bonds, said alkyl additionally optionally bearing a substitutent P selected from a group consisting of cyano, carboxy, 1H-tetrazol-5-yl, alkoxycarbonyl, carbamoyl, ureido, carbamoyloxy, acylamino, acyloxy, and an optionally substituted alkyl or phenyl (optionally oxidized) thio group: and M is an acidic group selected from a group consisting of carboxy, an acylsulphonamide residue and 1H-tetrazol-5-yl. The compounds of formula I are useful in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions. The invention also provides pharmaceutical compositions containing the formula I compounds, or their salts, and processes for the manufacture of the formula I compounds.

520794

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