Anti-allergy bicyclic phenol ethers

Details Anti-allergy bicyclic phenol ethers Anti-allergy bicyclic phenol ethers

C - Chemistry, Metallurgy

07

D

167/232, 260/279

C07D 401/12 (2006.01) C07D 307/83 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 1243320

ABSTRACT OF THE DISCLOSURE Bicyclic phenol ethers of the formula (I):- Image (I) wherein R1 is a hydrogen atom or a lower alkyl radical, R2 is a hydrogen atom or an acyl radical, X is an oxygen or sulphur atom or an -NH- group, Y is a -CO-CHR3- group or a -CO-C=CR4R5 group, R3 is a hydrogen atom, a lower alkyl radical, which can optionally be substituted by an aryl radical, or a cycloalkyl radical containing 3 to 7 carbon atoms and R4 and R5, which can be the same or different, are hydrogen atoms, lower alkyl radicals, alkenyl radicals containing 2 to 16 carbon atoms, which can optionally be substituted by an aryl radical, or an aryl radical or R4 and R5, together with the carbon atom to which they are attached, form a cycloalkyl ring con- taining 3 to 7 carbon atoms, and pharmaceutically accept- able, pharmacologically compatible salts thereof have an inhibiting action on anaphylactic reactions of the skin and of the bronchial system, even when administered orally in low dosages.

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