Methods of producing secreted receptor analogs and...

Details Methods of producing secreted receptor analogs and... Methods of producing secreted receptor analogs and...

C - Chemistry, Metallurgy

12

N

530/13, 167/37,

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/71 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12N 15/67 (2006.01) C12N 15/81 (2006.01) C12P 21/00 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340908

Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof. Pharmaceutical and diagnostic compositions utilizing the polypeptides are also disclosed.

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