Phenethanolamine derivatives

Details Phenethanolamine derivatives Phenethanolamine derivatives

C - Chemistry, Metallurgy

07

C

167/245, 167/276

C07C 217/10 (2006.01) A61K 31/135 (2006.01) C07C 33/46 (2006.01) C07C 43/174 (2006.01) C07C 43/178 (2006.01) C07C 43/225 (2006.01) C07C 45/00 (2006.01) C07C 47/277 (2006.01) C07C 49/255 (2006.01) C07C 59/66 (2006.01) C07C 229/38 (2006.01) C07D 303/40 (2006.01) C07D 309/12 (2006.01) C07D 317/54 (2006.01) C07D 317/58 (2006.01) C07D 319/06 (2006.01)

Patent

CA 1335999

Phenethanolamine derivatives are disclosed of formula Image wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12; Ar is phenyl or phenyl substituted by one or two halogen atoms, alkyl or alkoxy groups or by an alkylenedioxy group; R1 and R2 are hydrogen or alkyl provided that the sum total of carbon atoms in R1 and R2 is not more than 4; and the physiologically acceptable salts and solvates thereof. The compounds have a selective stimulant action at .beta.2-adrenoreceptors and may be used inter alia in the treat- ment of diseases associated with reversible airways ob- structions such as asthma and chronic bronchitis. The compounds may be formulated in conventional manner as pharmaceutical compositions with physiologically acceptable carriers or excipients. The compounds may be prepared, for example by alkyl- ation of an amine: Image where R3, R5 and R6 is hydrogen or a protecting group, followed by removal of any protecting group.

452288

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