C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 167/243
C07D 305/12 (2006.01) A61K 31/365 (2006.01) C07D 405/12 (2006.01)
Patent
CA 1316927
5153S/1353A 17541 TITLE OF THE INVENTION ANTIHYPERCHOLESTEROLEMIC .beta.-LACTONES ABSTRACT OF THE DISCLOSURE The compounds of the following general structural formula (I) Image (I) are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihyper- cholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyper- lipidemia and familial hypercholesterolemia.
567655
Girotra Narindar N.
Graham Donald W.
Yang Shu Shu
Merck & Co. Inc.
Swabey Ogilvy Renault
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