Tetralin derivatives, their preparation and their use

Details Tetralin derivatives, their preparation and their use Tetralin derivatives, their preparation and their use

C - Chemistry, Metallurgy

07

C

167/179, 260/537

C07C 39/23 (2006.01) C07C 35/36 (2006.01) C07C 45/44 (2006.01) C07C 45/46 (2006.01) C07C 47/548 (2006.01) C07C 47/57 (2006.01) C07C 47/575 (2006.01) C07C 49/683 (2006.01) C07C 49/697 (2006.01) C07C 49/747 (2006.01) C07C 49/757 (2006.01) C07C 49/792 (2006.01) C07C 49/798 (2006.01) C07C 49/813 (2006.01) C07C 49/835 (2006.01) C07C 49/84 (2006.01) C07C 63/66 (2006.01) C07C 65/19 (2006.01) C07C 65/38 (2006.01) C07C 247/24 (2006.01)

Patent

CA 1317973

ABSTRACT OF THE DISCLOSURE: Disclosed are novel tetralin derivative of the formula (I): Image (I) where R1 is hydrogen, C1-C4-alkyl, C1-C4-alkoxy or halogen, R2 is hydrogen, C1-C6-alkyl or C3-C6-cycloalkyl, X is -CH2-CO-, -CH2-CHOH, -CH2-C(R4)OH-, -CH2-C(OCOR4)H-, -CH2-C(R4)(OCHOR5)-, -CHOH-CHOH-, -CH=CH-, -CH(OCOR4) -CH(OCOR4)-, -CH2-CH(OR4)- (where R4 and R5 are each C1-C4- alkyl) and R3 is nitrile, C2-C10-ketal or -CH(R7)(R8)- or -CO-R9, where R7 is hydrogen or C1-C3-alkyl, R8 is hydrogen, C1-C3-alkyl or -OR10 or -NR11R12 (where R10, R11 and R12 are each hydrogen, C1-C4-alkyl, C2-C20-alkanoyl or unsubstituted or substituted benzoyl) and R9 is hydrogen, halogen, C1-C4- alkyl, azido, or -OR13 (where R13 is hydrogen or C1-C8-alkyl or is C2-C6 alkyl which is substituted by one or more hydroxyl groups or a C1 -C4 - alkoxy group, or is aryl or aralkyl) and, where relevant, its physiologically tolerated salts. These derivatives are useful in the therapy of dermatological dis- orders and the prophylactic and therapeutic treatment of precanceroses and tumors.

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