Therapeutic peptides

Details Therapeutic peptides Therapeutic peptides

C - Chemistry, Metallurgy

07

K

530/7.2

C07K 7/23 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1296486

412-1521 Abstract of the Disclosure A decapeptide of the formula: Ac-A1 -A2-D-Trp-Ser-Tyr-A3-A4-A5-A6- A7-NH2 wherein each A1 and A2, independently, is D-Trp, D- .beta. -Nal, or D-p-X-Phe, wherein X is a halogen or CH3; A3 is D- .beta. -Nal, D-Trp, D-Lys, D-Arg, D-homo-Arg, D-diethyl-homo-Arg, or D-p-X-Phe, wherein X is a halogen or CH3; A4 is Phe, Tyr, pentafluoro- Phe, Trp, .beta. -Nal, or p-X-Phe, wherein X is a halogen or CH3; A5 is Arg or Lys A6 is Pro or hydroxy-Pro; and A7 is Gly or D-Ala; or a pharmaceutically acceptable salt thereof. These compounds find use in inhibiting the release of LH-RH and, since they exhibit a long duration of activity, minimize both the amountand the frequency of dosages.

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