C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.102
C12N 5/02 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/08 (2006.01) C12N 5/16 (2006.01)
Patent
CA 1198066
PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES BY HUMAN HYBRIDOMAS ABSTRACT The present invention provides a stable, continuous human myeloma cell line which is capable of hybridization with antibody-producing cells of humans and other animals, the cell line being a mutant of GM 1500 human B cells and being deficient in hypoxanthine phosphoribosyltransferase. The invention also comprises processes for the production of hybrid cells employing the stable, HPRT-deficient human myeloma cell line, and processes for the production of antibodies employing such hybrid cells.
389655
Sim & Mcburney
The Wistar Institute
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