Recombinant herpes simplex viruses, vaccines and methods

Details Recombinant herpes simplex viruses, vaccines and methods Recombinant herpes simplex viruses, vaccines and methods

C - Chemistry, Metallurgy

12

N

167/130, 195/1.2

C12N 15/38 (2006.01) A61K 39/245 (2006.01) C07K 14/035 (2006.01) C12N 7/01 (2006.01) C12N 15/869 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1305081

ABSTRACT OF THE DISCLOSURE Recombinant herpes viruses useful as effective ingredients in vaccines against both virulent HSV-1 and HSV-2 are disclosed. Methods of preparing the recombinant viruses, vaccines incorporating the viruses, and methods of immunizing a human host by inoculation with the vaccines are also disclosed. The genomes of the recombinant viruses each comprise a mutant of the HSV-1 genome from which a portion thereof responsible for neurovirulence yet nonessential for growth is deleted. A gene from the HSV-2 genome responsible for coding an immunity-inducing glycoprotein is inserted in the mutant genome between the end points of deletion therein.

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