Antidiabetic compositions

Details Antidiabetic compositions Antidiabetic compositions

A - Human Necessities

61

K

167/224, 167/231

A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/64 (2006.01)

Patent

CA 1194800

Abstract Certain novel oral antidiabetic compositions are disclosed. These pharmaceutical compositions involve the concomitant use of two different organic chemical compounds each chosen from a separate class of known hypoglycemic agents. One class of agents involves certain known oxazolidine-2,4-dione compounds (A), while the other class is primarily concerned with a series of known hypoglucemic sulfonylureas (B). Preferred embodiments involve the use of 5-(3-thienyl)oxazolidine- 2,4-dione, 5-(4-ethoxy-3-thienyl)oxazolidine-2,4-dione, 5-(2-methoxy-6-fluorophenyl)oxazolidine-2,4-dione, 5-(2-methoxy-6-chluorophenyl)oxazolidine-2,4-dione or 5-(2-ethoxy-5-chluoro-3-pyridyl)oxazolidine-2,4-dione as compound (A) in conjunction with either chlorpropamide or glipizide as compound (B). Various methods for administering these compounds in combination and/or in a concomitant manner are provided.

422410

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