Enzymatic detection of bacterial capsular polysaccharide...

Details Enzymatic detection of bacterial capsular polysaccharide... Enzymatic detection of bacterial capsular polysaccharide...

C - Chemistry, Metallurgy

12

N

195/123, 195/33.

C12N 9/14 (2006.01) C12N 7/00 (2006.01) C12Q 1/04 (2006.01) C12Q 1/34 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1266446

ABSTRACT A substantially pure enzyme which hydrolyzes a polymer containing an ?2,8-linked N-acetyl neuraminic acid is obtained from K1-specific bateriopilages and used for assays of bacterial polysaccharides in samples such as cerebrospinal fluid for testing for various disorders such as bacterial meningitis, septicemia, bacteremia, and the like. The enzyme may also be used therapeutically in treating such disorders by attacking cells which have a increased level of a polymer containing ? 2,8-linked N-acetyl neuraminic acid.

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