Nitro-substituted aromatic or hetero-aromatic compounds for...

Details Nitro-substituted aromatic or hetero-aromatic compounds for... Nitro-substituted aromatic or hetero-aromatic compounds for...

C - Chemistry, Metallurgy

07

D

167/233, 260/315

C07D 233/91 (2006.01) A61K 31/41 (2006.01) C07D 233/95 (2006.01) C07D 249/10 (2006.01) C07D 249/14 (2006.01)

Patent

CA 1332738

ABSTRACT A compound for treating a patient having a solid tumour in which it is known or suspected that hypoxic cells are present, which is a compound of formula (A): Image (A) wherein X represents a nitro-substituted aromatic or hetero-aromatic group with a one-electron reduction potential at pH 7 from -250 to -500 mV; each of R'1 to R'5 independently represents hydrogen or an alkyl, hydroxyalkyl, aryl, aralkyl or alkaryl group; m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclisation reaction; or a physicologically acceptable acid addition salt thereof.

584851

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