G - Physics – 01 – N
Patent
G - Physics
01
N
167/44, 150/8
G01N 33/543 (2006.01) B01L 3/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/564 (2006.01) G01N 33/68 (2006.01) G01N 35/00 (2006.01) G01N 35/10 (2006.01)
Patent
CA 1335345
A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou- sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con- tained within a reaction well which is adapted to con- tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi- tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.
607328
Defreese James Douglas
Durley Benton Alvin III
Merkh Carl Walter
Abbott Laboratories
Goudreau Gage Dubuc
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