Therapeutic lhrh analogs

Details Therapeutic lhrh analogs Therapeutic lhrh analogs

C - Chemistry, Metallurgy

07

K

530/7.2

C07K 7/23 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1257950

Abstract of the Disclosure A compound having the formula K-His-Trp-Ser-Tyr- M-Q-Arg-Pro-T, wherein K is N-Acetyl-Sarconsine or pGlu: is D-Phe, D-Trp, D-.beta. -Nap.hthylalanine, or D-4-X-Phe, wherein X is OH, F, Cl, Br, or Me: Q is Leu, Phe, 4-X-Phe, Trp, or .beta.-Naphthylamine (wherein X is OH, F, Cl, Br, or Me), or an N-Me-derivative thersof: and T is Gly-NH2, NHCH3, NHCH2CH3, or NHCH2CH2CH3; provided that, when Q is Leu or N-Me-Leu, K cannot be pGlu: or a phar~aceutically acceptable salt thereof.

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