Thyronine analogous compounds

Details Thyronine analogous compounds Thyronine analogous compounds

C - Chemistry, Metallurgy

07

D

167/160, 167/211

C07D 213/65 (2006.01) A61K 31/395 (2006.01) C07C 45/67 (2006.01) C07C 45/71 (2006.01) C07D 213/64 (2006.01) C07D 237/12 (2006.01) C07D 237/14 (2006.01) C07D 413/12 (2006.01)

Patent

CA 1319148

11870 A B S T R A C T Compounds of structure (I) Image (I) in which, R1 is -CH2CR2R3NR4R5 or YCOR6; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or -COR6; R4 is hydrogen or C1-4alkyl; R5 is hydrogen, C1-4alkyl or C1-4alkanoyl; R6 is hydroxy, C1-4a1koxy, or -NR4R5; Y is a bond or C1-4alkylene; R7 and R8 are the same or different and are each hydrogen, halogen, C1-4alkyl, nitro or amino; X is oxygen, sulphur, or CH2; R9 is hydroxy or a bioprecursor thereof; R10 is hydrogen or C1-4alkyl; and Ar is 4-hydroxyphenyl, 5-hydroxy-2-pyridyl, 6-oxo-3(1H)-pyridyl or a 6-oxo-3(1H)-pyridazinyl group and pharmaceutically acceptable salts thereof, processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy as antihyperlipidaemic agents.

499485

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