Oral therapeutic system having systemic action

A - Human Necessities – 61 – K

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A61K 31/55 (2006.01) A61K 9/00 (2006.01)

Patent

CA 1302267

4-16040/+ Oral therapeutic system having systemic action Abstract of the Disclosure The invention relates to a therapeutic system for peroral adminis- tration and having systemic action, which system is in the form of a coated and/or laminated monocompartment system for administering carbamazepine. The therapeutic system comprises a) a wall made of a material which is permeable to water and impermeable to the components of the drug-containing core, b) a core containing finely particulate carbamazepine as drug and, as auxiliaries, a protective colloid that inhibits the crystal growth of carbamazepine in the presence of water, a swellable hydrophilic polymer and, optionally, a water-soluble compound for inducing osmosis and/or further pharmaceutically acceptable excip- ients, and c) a passageway through the wall a) for delivering the core com- ponents to the environmental body fluid. The therapeutic system can are used as anticonvulsive for the treatment of convulsive states, especially epileptic states.

543746

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