Preparation of (d-trp.sup.6)-lh-rh via the heptapeptide...

Details Preparation of (d-trp.sup.6)-lh-rh via the heptapeptide... Preparation of (d-trp.sup.6)-lh-rh via the heptapeptide...

C - Chemistry, Metallurgy

07

K

530/7.06, 530/7.

C07K 7/23 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1178950

AHP-7616 ABSTRACT OF THE DISCLOSURE Herein is described a process for preparing the decapeptide Pyr- His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 ([D-Trp6]-LH-RH) by coupling Pyr-His-Trp-NHNH2 with H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2. [D-Trp6]- LH-RH had been established to be an efficient agent for causing release of luteinizing hormone and follicle-stimulating hormone in mammals.

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