Pyrimidine-thioalkyl pyridine derivatives, a process for...

Details Pyrimidine-thioalkyl pyridine derivatives, a process for... Pyrimidine-thioalkyl pyridine derivatives, a process for...

C - Chemistry, Metallurgy

07

D

167/22, 260/260

C07D 401/12 (2006.01) A61K 31/505 (2006.01)

Patent

CA 1260938

ABSTRACT The invention relates to pyrimidine-thioalkyl pyridine derivatives corresponding to the following general formula Image (I) in which R1 to R4, independently of one another, represent hydrogen, lower alkyl, halogen, amino or hydroxy groups, R5 represents a free electron pair or a lower alkyl group, a halogen atom, m has the value 0 or 1, the pyrimidine-thioalkyl group being bonded in the 2- , 3- or 4-position of the pyridine ring, and to therapeutically compatible acid addition salts thereof. The new compounds according to the invention are surprisingly distinguished by high bronchosecretolytic and mucolytic activity and by antiphlogistic activity which are of a therapeutic value. The invention also relates to a process for producing the new pyrimidine- thioalkyl pyridine derivatives and to medicaments containing these compounds.

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