Compositions and their preparation

Details Compositions and their preparation Compositions and their preparation

C - Chemistry, Metallurgy

07

D

260/294.2

C07D 213/64 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 213/85 (2006.01) C07D 471/04 (2006.01)

Patent

CA 1242202

ABSTRACT OF THE DISCLOSURE 1-R"-3-Q-4-R'-5-R-1,6-naphthyridin-2(1H)-ones (I) or salts thereof, where R is lower-alkyl, R' is hydro- gen or methyl, R" is hydrogen or lower-alkyl, and Q is hydrogen, hydroxy, amino, cyano, carbamyl, carboxy or aminocarbamyl, are useful as cardiotonic agents (I, Q is hydrogen, hydroxy, amino, cyano or carbamyl) and/or intermediates therefor (I, Q is carboxy, aminocarbamyl, hydrogen, amino, cyano or carbamyl). Also shown are 3-Q'-4-R'-5-(RCO)-6-[2-(di-lower-alkylamino)ethenyl]- 2(1H)-pyridinones (II) or salts thereof, where R and R' are as above and Q' is hydrogen or cyano, which are useful as cardiotonics (II, Q' is hydrogen) and/or inter- mediates (II, Q' is cyano or hydrogen). Processes for preparing the compounds of formulas I and II are shown.

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