Chemotherapeutic agent and tracer composition and system for...

Details Chemotherapeutic agent and tracer composition and system for... Chemotherapeutic agent and tracer composition and system for...

A - Human Necessities

61

K

167/46, 128/81.2

A61K 49/00 (2006.01) G01N 33/52 (2006.01)

Patent

CA 1178199

Abstract A therapeutic composition and system suitable for extracorporeal treatment of whole blood comprises a dialyzable chemotherapeutic agent and a dialyzable fluorescable tracer means. The removal rate of the fluorescable tracer compound from treated blood during hemodialysis is a function of the removal rate of unreacted chemotherapeutic agent present. The residual chemotherapeutic agent concentration after hemodialysis is ascertained by measuring the concentration of the fluorescable tracer compound in a dialysate using fluorometric techniques. The system includes a continuous confined flow passageway for communicating with a patient's cardiovascular system and defining an extracorporeal loop within which a portion of the patient's body fluid is circulated, a peristaltic pump means capable of transporting a substantially constant volume of a body fluid per unit time through the extracorporeal loop and occluding a segment of the extracorporeal loop, and a body fluid treatment means such as a hemoreactor situated within the occluded segment of the extracorporeal loop. The hemoreactor comprises a length of tubing having a plurality of coils wound in a plurality of concentric helices to generate a centrifugally induced, transverse double toroidal secondary flow within the tube to gently mix the blood and therapeutic composition.

375932

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