Pyrrolacetic amides having antiinflammatory activity

C - Chemistry – Metallurgy – 07 – D

Patent

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260/326, 260/280

C07D 207/337 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01)

Patent

CA 1207769

"Pyrrolacetic amides having antiinflammatory acitivity" ABSTRACT OF THE DISCLOSURES N-monosubstituted and N,N-disubstituted amides of the 1-methyl-5-p-toluoylpyrrole-2-acetic acid, which are active as antiinflammatory, analgesic, antipyretic, antisecretive and antitussive agents, are disclosed. These amides are prepared by reacting an amine with an activated derivative of the 1-methyl-5-p-toluoylpyrrole-2- -acetic acid of formula Image wherein X is an activating group suitable for promoting the formation of an amide bond.

421878

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