Process for the preparation of 3-carboxy-1-...

Details Process for the preparation of 3-carboxy-1-... Process for the preparation of 3-carboxy-1-...

C - Chemistry, Metallurgy

07

D

260/326

C07D 207/34 (2006.01)

Patent

CA 1206479

ABSTRACT OF THE DISCLOSURE There is described a process for the preparation of 3-carboxy-1-methylpyrrol-2-acetic acid of formula (I): (I) Image in which a carboxylic compound chosen between acetone dicarboxy- lic acid and its alkaline salts, is reacted in an aqueous medium with methylamine and chloroacetaldehyde, at a temperature between 5°C and about 25°C. The resulting product is useful as an intermediate in organic synthesis; in particular for the preparation of 5-aryloyl-pyrrol-alkanoic acids which are anti- inflammatory agents.

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