Omt ester derivatives

Details Omt ester derivatives Omt ester derivatives

C - Chemistry, Metallurgy

07

H

260/230.37

C07H 17/08 (2006.01)

Patent

CA 1189503

Abstract of the Invention Ester derivatives of 5-O-mycaminosyl tylo- nolide (OMT) of the formula (I): Image wherein R and R1 are selected from hydrogen, optionally substituted C1-C5-alkanoyl or optionally substituted benzoyl, phenylacetyl, or phenylpropionyl; R2 is Image ; m is 1 or 2, and R3 is 3-pyridyl or a group of the formula (I): Image where R5 and R6 are independently hydrogen, methyl, ethyl, methoxy, or nitro, X is O or S, and n is 0 or 1; provided that when R1 is other than hydrogen, R must also be other than hydrogen; and the pharmaceutically acceptable acid addition salts thereof; which are use- ful highly potent antibiotics, are provided.

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