Sparsomycin derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/46 (2006.01) C07D 239/54 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1250577

ABSTRACT Sparsomycin derivatives of the formula Image wherein X and y are each independently an oxo or an imino group; n is O or the integer 1 or 27 R1 is a hydrogen or 1 to 4 carbon alkyl group; R2 is a hydrogen, a 1 to 4 carbon alkyl, a 2 to 5 carbon acyl or a benzoyl group; and R is a 1 to 6 carbon alkyl, 3 to 8 carbon alkenyl, cyanomethyl carhoxymethyl, carbalkoxymethyl wherein the alkoxy moiety is a 1 to 4 carbon alkoxy group, nitromethyl, alkylcarbonylmethyl wherein the alkyl moiety is a 1 to 4 carbon alkyl group, pyridyl, furanyl, or furfuryl group or a phenyl or benzyl group optionally substituted by a methylenedioxy or one to two halogen, 1 to 4 carbon alkyl, 1 to 4 carbon alkoxyr 1 to 4 carbon alkylthio, hydroxy, nitro or cyano groups or a pharmaceutically acceptable acid addition salt thereof. Also described are their use as antiprotozoals and antibacterials.

486836

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