C - Chemistry – Metallurgy – 07 – G
Patent
C - Chemistry, Metallurgy
07
G
167/130
C07G 99/00 (2009.01) A61K 35/12 (2006.01) C12P 1/00 (2006.01)
Patent
CA 1253804
A CELLULAR VIRAL INHIBITOR COMPOSITION ABSTRACT A composition for the treatment and prophylaxis of viral infections in mammals is provided. The composition includes an amount of a contact-blocking viral inhibitor (CVI) in a diluent sufficient to elevate the concentration of the viral inhibitor in a mammal's tissue above the naturally occurring concentration in that same tissue. Methods for purifying and concentrating CVI are presented. The cellular viral inhibitor is characterized by broad antiviral activity, potency, reversible inhibition of viral attachment, cross species activity and molecular size. Natural levels of CVI range from 6 U/0.1 ml in tears to 400 U/0.1 ml in gastric secretions, with titers between these ranges found in colostrum, milk, plasma, saliva and urine. Biochemical characterization of the CVI indicates that it resists denaturation by heat, acid and alkali, and it exhibits a molecular size on the order of 2500 daltons.
481249
Baron Samuel
Mckerlie M. Louese
Meredith & Finlayson
The Board Of Regents The University Of Texas System
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