Process for obtaining aminated derivatives of pyridazine...

Details Process for obtaining aminated derivatives of pyridazine... Process for obtaining aminated derivatives of pyridazine...

C - Chemistry, Metallurgy

07

D

260/245.7

C07D 413/00 (2006.01) C07D 237/20 (2006.01) C07D 409/04 (2006.01)

Patent

CA 1218063

ABSTRACT OF THE DISCLOSURE The present invention relates to a process for obtain- ing aminated derivatives of pyridazine of formula: Image (I) in which: - R1 designates a 2-thienyl, 3-thienyl or cyclohexyl group; - R2 represents a lower alkyl group (1 to 4 atoms of carbon), or an atom of hydrogen as well as the salts of said derivatives with the acids, comprising the steps of reacting a chlorinated derivative of formula Image in which R1 and R2 are as defined hereinabove, with an amine of formula: Image reaction being carried out in a solvent such as an alcohol, hot in the presence of a hydracid acceptor, and possibly of converting the derivative thus obtained into a pharma- ceutically acceptable salt. The products have therapeutic application as antidepressants.

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