Purification of synthetic oligomers

Details Purification of synthetic oligomers Purification of synthetic oligomers

C - Chemistry, Metallurgy

07

H

260/462, 195/1.1

C07H 15/10 (2006.01) C07H 19/16 (2006.01) C07H 21/00 (2006.01)

Patent

CA 1293938

PURIFICATION OF SYNTHETIC OLIGOMERS ABSTRACT OF THE DISCLOSURE Oligomers and polymers are prepared substan- tially free of error sequences by sequentially adding monomers, which are terminally blocked and have active functionalities protected, to a growing chain bound to a support through a selectively cleavable linkage. After each addition, unblocked terminal groups are capped. At the completion of monomer addition, enzyma- tic hydrolysis interfering protecting groups axe removed along with the capping group and failure sequences en- zymatically degraded. The terminal blocking group may then be removed. The completed oligomer or polymer may be cleaved from the support prior or subsequent to en- zymatic degradation but after completion of the sequent

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