Process for the preparation of a furan derivative

Details Process for the preparation of a furan derivative Process for the preparation of a furan derivative

C - Chemistry, Metallurgy

07

D

260/367.3

C07D 307/52 (2006.01) C07D 203/12 (2006.01)

Patent

CA 1171096

ABSTRACT Process for the preparation of a furan derivative The invention relates to a process for the preparation of ranitidine of formula (I) (I) Image which comprises reacting a thiol of formula (II) (II) Image with an alkylating agent of formula (III) (III) Image where L is a leaving group, preferably halogen. The invention also relates to novel intermediates, the thiol of formula (II) (II) Image in the form of a stable acid addition salt, and the isothiourea of formula (IV) Image (IV) and stable acid addition salts thereof.

368083

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