Antiulcer (alkyldithio) quinoline derivatives

Details Antiulcer (alkyldithio) quinoline derivatives Antiulcer (alkyldithio) quinoline derivatives

C - Chemistry, Metallurgy

07

D

167/222, 260/259

C07D 401/04 (2006.01) A61K 31/505 (2006.01) C07D 401/12 (2006.01)

Patent

CA 1317953

72222-122 PATENT PC7443/RKB ANTIULCER (ALKYLDITHIO)QUINOLINE DERIVATIVES ABSTRACT Quaternary 8-(alkyldithio)-1-(2-pyrimidyl)- quinolinium salts, inhibitors of the H+/X+ ATPase enzyme, are useful in the treatment of ulcers, and have the formula: Image ---(I) (wherein W? is a pharmaceutically-acceptable anion; R is (C1-C5)alkyl or benzyl; Q is H, F, Cl, NO2, (C1-C5)alkyl, CF3, (C1-C5)alkoxy or (C2-C4)alkanoylamino; X is H, (C1-C5)alkyl or (C1-C5)alkoxy; Y is H, F, Cl, Br, (C1-C5)alkyl or (C1-C5)alkoxy; and Z is H, (C1-C5)alkyl, (C5-C7)cycloalkyl, (C1-C5) alkoxy, (C5-C7)cycloalkoxy, phenoxy or benzyloxy).

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