Process for preparing a retard product containing diltiazem...

Details Process for preparing a retard product containing diltiazem... Process for preparing a retard product containing diltiazem...

A - Human Necessities

61

K

167/209

A61K 31/55 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01)

Patent

CA 1327006

ABSTRACT A process is described for preparing a solid form for oral administration, in hard gelatin capsules which contain pellets based on diltiazem, possessing controlled release of the active substance "in vitro", such that a slow delivery and a prolonged absorption are possible "in vivo" with blood levels that are active following the administration of a single 180-mg dose every 24 hours, preferably in combination with a proportionately variable amount of immediate-delivery pellets in order to obtain good blood levels even in the initial phase of absorption.

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