Substituted tyrosyl alanine dipeptide amides

Details Substituted tyrosyl alanine dipeptide amides Substituted tyrosyl alanine dipeptide amides

C - Chemistry, Metallurgy

07

K

530/7.12, 167/10

C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1258950

ABSTRACT The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: Image and the pharmaceutically acceptable acid addition salts thereof wherein R1 represents straight or branched lower alkyl having 1 to 4 carbons; R2 represents hydrogen, hydroxy, -OCO2R1 substituent or lower alkyl having 1 to 4 carbons; R3 represents a hydrogen or lower alkyl having 1 to 6 carbons; R4 and R5 may be the same or different and represent hydrogen or lower alkyl having 1 to 6 carbons; n is 1 to 6; X represents a hydrogen, hydroxy or OCO2R1 substituent; A represents a cyclohexyl, phenyl or phenyl substituted with one or more lower alkyls containing 1 to 6 carbons, one or more amino, hydroxy, halogen, nitro or lower alkoxy substituent having 1 to 6 carbons; V represents the asymmetric carbon that may be racemic or have the D or L configuration; W represents the asymmetric carbon when R4 and R5 are not the same that may optionally be racemic or have the D or L configuration. These compounds are useful as analgesic and/or antihypertensive agents.

474423

Affiliated with

Also associated with

Rating

Substituted tyrosyl alanine dipeptide amides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted tyrosyl alanine dipeptide amides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted tyrosyl alanine dipeptide amides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1233089