C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/15.12, 167/1
C07K 14/535 (2006.01) A61K 38/19 (2006.01) C07K 1/113 (2006.01) C07K 16/24 (2006.01) C07K 17/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1340810
A modified polypeptide having human granulocyte colony stimulating factor (hG-CSF) activity comprising a polypeptide having hG-CSF activity with at least one amino group thereof substituted with a group of the formula R1~OCH2CH2~n X-R2- (I) wherein R1 is an alkyl or alkanoyl group; n is an optionally variable positive integer; X is O, NH or S; R2 is Image [where R3 is OH, Cl, O-(CH2CH2O)n -R1, where R1 and n are as defined above, Y may not be present or represents Z-(CH2)p CO, where Z is O, S or NH and p is an optionally variable positive interger], or (CO)m-(CH2)l CO, where m is 0 or 1; 2 is an optionally variable positive integer, which can provide an enhanced peripheral leukocyte (granulocyte) increasing effect with improved stability and residence time in the blood and, as such, can be used advantageously in clinical medicines.
595089
Morimoto Makoto
Okabe Masami
Yamasaki Motoo
Yokoo Yoshiharu
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Kyowa Hakko Kirin Co. Ltd.
Kyowa Hakko Kogyo Co. Ltd.
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