Triazolo (4,3-b) pyridazines, process for their preparation...

Details Triazolo (4,3-b) pyridazines, process for their preparation... Triazolo (4,3-b) pyridazines, process for their preparation...

C - Chemistry, Metallurgy

07

D

167/224, 260/264

C07D 487/04 (2006.01) A61K 31/50 (2006.01) C07C 45/58 (2006.01) C07C 47/277 (2006.01) C07D 237/10 (2006.01) C07D 237/12 (2006.01) C07D 237/14 (2006.01) C07D 237/20 (2006.01) C07D 303/48 (2006.01) C07D 307/60 (2006.01)

Patent

CA 1249276

Entitled : Triazolo[ 4,3-b]pyridazines, process for their preparation and pharmaceutical compositions containing them. in the names of : Jacques BOURGUIGNON Jean-Pierre CHAMBON Camille Georges WERMUTH assigned to : SANOFI ABSTRACT OF THE DISCLOSURE The invention relates to 1,2,4-triazolo [ 4,3-b]pyridazines substituted in the 7-position of formula : Image (I) in which R represents hydrogen, a lower alkyl group, a phenyl group, a chlorophenyl group or a benzyl group and R1 represents a phenyl, halogenophenyl, trifluoro- methylphenyl, lower alkyl-phenyl or lower alkoxy-phenyl group or a phenyl-lower alkyl group, or one of its pharmaceutically acceptable salts. Said compounds antagonize the effects of benzodiazepines and therefore are useful as antidotes in the abuse of benzodiazepines and compounds acting on benzodiazepine receptors.

477357

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