8-substituted quinoline derivatives and their use in therapy

Details 8-substituted quinoline derivatives and their use in therapy 8-substituted quinoline derivatives and their use in therapy

C - Chemistry, Metallurgy

07

D

167/226, 260/281

C07D 215/42 (2006.01) A61K 31/47 (2006.01) C07D 215/18 (2006.01) C07D 215/44 (2006.01)

Patent

CA 1332839

Compounds of structure (I) Image (I) in which R1 is hydrogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy- C1-6-alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-6alkyl, phenyl, phenylC1-6alkyl, the phenyl groups being optionally substituted; R2 is hydrogen, C1-6alkyl, C1-6alkoxy, amino, C1-6-alkylthio, halogen, cyano, hydroxy, carbamoyl, carboxy, C1-6alkanoyl or trifluoromethyl; m is 1, 2 or 3; p is 0 to 4; R3 is hydroxyC1-6alkyl, polyhydroxyC1-6alkyl, C1-6alkoxyC1-6alkyl, hydroxyC1-6alkoxy, polyhydroxy- C1-6alkoxy, C1-6alkoxyC1-6alkoxy or hydroxyC1-6alkoxy- C1-6alkoxy; and R4 is hydrogen, hydroxy, C1-6alkyl, or C1-6alkoxy, processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors of gastric acid secretion.

591638

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