4-r'-5-q-1,6-naphthyridin-2(1h)-one

Details 4-r'-5-q-1,6-naphthyridin-2(1h)-one 4-r'-5-q-1,6-naphthyridin-2(1h)-one

C - Chemistry, Metallurgy

07

D

167/231, 260/273

C07D 471/04 (2006.01) A61K 31/44 (2006.01)

Patent

CA 1244830

22749-302 ABSTRACT OF THE DISCLOSURE 4-R'-5-Q-1,6-naphthyridin-2(1H)-ones (I), where R' is hydrogen or methyl and Q is hydroxymethyl, 1-hydroxy- ethyl alkanoyloxymethyl or l-alkanoyloxyethyl, are pro- duced by first reacting 4-R'-5-acetyl(or n-propanoyl)- 6-[2-(di-lower-alkylamino]-2(1H)-pyridinone [III] with hydroxylamine or salt thereof to produce 4-R'-5-Q'-1,6- naphthyridin-2(1H)-one-6-oxide (II), where R' is defined as above and Q' is methyl or ethyl; next reacting II with an alkanoic anhydride to produce I where Q is alkanoyl- oxymethyl or l-alkanoyloxyethyl; and, then hydrolyzing said alkanoyloxymethyl or -ethyl compound to produce I where Q is hydroxymethyl or l-hydroxyethyl. Also shown is the cardiotonic use of II and I where Q is hydroxy- methyl, 1-hydroxyethyl or alkanoyloxymethyl.

460530

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