Purification of 5-pyrimidinecarboxamides

Details Purification of 5-pyrimidinecarboxamides Purification of 5-pyrimidinecarboxamides

C - Chemistry, Metallurgy

07

D

260/258, 260/229

C07D 239/66 (2006.01) C07D 239/68 (2006.01) C07H 19/06 (2006.01)

Patent

CA 1284641

TITLE: PURIFICATION OF 5-PYRIMIDINECARBOXAMIDES ABSTRACT OF THE DISCLOSURE A process is provided for the purification to highly purified states of 5-Pyrimidinecarboxamides which are essentially insoluble in both organic and inorganic solvents. The 5-Pyrimidinecarboxamide to be purified is contacted with an organic base to form an adduct. The adduct is purified through recrystallization and the desired 5-Pyrimidinecarboxamide is regenerated from the adduct in highly purified form with acid. Additionally, an adduct resulting from the combination of a 5-Pyrimidinecarboxamide with an organic base is provided, which adduct is capable of being purified using recrystallization techniques, where the 5-Pyrimidine- carboxamide is not itself capable of being so purified due to its relative insolubility in organic and inorganic sol- vents. The 5-pyrimidinecarbonamides exhibit anti- leukemia and anti-tumor activity.

509423

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