Sulphonamide derivatives of 2-amino-1,3,4,6,7,116-...

Details Sulphonamide derivatives of 2-amino-1,3,4,6,7,116-... Sulphonamide derivatives of 2-amino-1,3,4,6,7,116-...

C - Chemistry, Metallurgy

07

D

260/271.5

C07D 455/06 (2006.01)

Patent

CA 1247622

- 42 - ABSTRACT BENZOQUINOLIZINES The invention concerns benzoquinolizines of general formula Image (I) and their pharmaceutically acceptable acid addition salts. In formula (I), R represents hydrogen or lower alkyl, R1 and R2 which may be the same or different each represent hydrogen, lower alkyl, lower alkoxy or halogen, R3 and R4 which may be the same or different each represents lower alkyl, halo(lower)alkyl or aryl and A represents a lower alkylene group having 1 to 3 carbon atoms in the chain between the two N atoms. The compounds possess .alpha.2- adrenoceptor antagonistic activity in warm blooded animals.

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