2-oxindole-1-carboxamide intermediates

Details 2-oxindole-1-carboxamide intermediates 2-oxindole-1-carboxamide intermediates

C - Chemistry, Metallurgy

07

D

260/207.7

C07D 209/34 (2006.01) C07D 209/56 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1288422

ABSTRACT The invention relates to a compound of the formula II: Image (II) wherein X is hydrogen, fluoro, chloro, bromo, alkyl having 1 to 4 carbons, cycloalkyl having 3 to 7 carbons, alkoxy having 1 to 4 carbons, alkylthio having 1 to 4 carbons, trifluoromethyl, alkylsulfinyl having 1 to 4 carbons, alkylsulfonyl having 1 to 4 carbons, nitro, phenyl, alkanoyl having 2 to 4 carbons, benzoyl, thenoyl, alkanamido having 2 to 4 carbons, benzamido or N,N- dialkylsulfamoyl having 1 to 3 carbons in each of said alkyls; and Y is hydrogen, fluoro, chloro, bromo, alkyl having 1 to 4 carbons, cycloalkyl having 3 to 7 carbons, alkoxy having 1 to 4 carbons, alkylthio having 1 to 4 carbons or trifluoro- methyl; or X and Y when taken together are a 4,5-, 5,6- or 6,7- methylenedioxy group or a 4,5-, 5,6- or 6,7-ethylenedioxy group; or X and Y when taken together and when attached to adjacent carbon atoms, form a divalent radical Z, wherein Z is selected from Image , Image , Image , Image and Image wherein W is oxygen or sulfur. The compounds are useful as intermediates in the preparation of analgesic and antiinflammat- ory agents.

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