2-azabicyclo [3.1.0] hexane derivatives and a process for...

Details 2-azabicyclo [3.1.0] hexane derivatives and a process for... 2-azabicyclo [3.1.0] hexane derivatives and a process for...

C - Chemistry, Metallurgy

07

D

260/317

C07D 209/52 (2006.01) C07D 221/04 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1267902

ABSTRACT OF THE DISCLOSURE The invention relates to compounds of the formula IIIa or IIIb. Image (IIIa) with mirror image Image (IIIb) with mirror image wherein W denotes hydrogen or a group esterifying carboxyl, and a process for the preparation of compounds of the formula IIIa or IIIb. The compounds of the formula IIIa or IIIb are intermediates in the process for the preparation of compounds of the formula I: Image (I) The compounds of the formula I and their salts have a long-lasting and strong hypotensive effect. They are potent inhibitors of angiotension converting enzyme (ACE inhibitors) and can be employed to control hypertension of a variety of etiologies.

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