C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/246
C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/535 (2006.01)
Patent
CA 1310965
Jean GUBIN, Pierre CHATELAIN, Marcel DESCAMPS and Dino NISATO. INDOLIZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THE COMPOSITIONS CONTAINING THEM. ABSTRACT OF THE DISCLOSURE The invention relates to new indolizine derivatives of general formula : Image in which : B represents a -S-, -SO- or -S02- group, R represents hydrogen, a linear or branched-alkyl radical, a cycloalkyl radical containing at most 6 carbon atoms or a phenyl group which is unsubstituted or substituted with one or more substituents, which may be identical or different, selected from halogen atoms and from lower alkyl, lower alkoxy or nitro groups, R1 and R2, which are identical or different, each represent hydrogen, a methyl or ethyl radical or a halogen, A represents a linear-or branched-alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxypropylene radical, R3 represents a linear-or branched-alkyl radical or a radical of formula : Alk-R5 in which Alk represents a single bond or a linear-or branched- alkylene radical having from 1 to 5 carbon atoms and R5 represents a pyridyl, phenyl, 2,3-methylenedioxyphenyl or 3,4-methylenedioxyphenyl radical or a phenyl group substitu- ted with one or more substituents, which may be identical or different, selected from halogen atoms, lower alkyl groups or lower alkoxy groups, R4 represents hydrogen or an alkyl radical, or R3 and R4, when taken together, represent an alkylene or alkenylene radical having from 3 to 6 carbon atoms and optionally substituted with a phenyl radical or optionally interrupted by -O-, -NH-, -N= or -?-R6, R6 representing a lower alkyl or phenyl radical, as well as the pharmaceu- tically acceptable salts of these derivatives These derivatives are useful in the treatment of certain pathological syndromes of the cardiovascular system.
529512
Chatelain Pierre
Descamps Marcel
Gubin Jean
Nisato Dino
Robic
Sanofi-Aventis
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