Basically substituted 4-phenyl-4,5,6,7-tetrahydro-...

Details Basically substituted 4-phenyl-4,5,6,7-tetrahydro-... Basically substituted 4-phenyl-4,5,6,7-tetrahydro-...

C - Chemistry, Metallurgy

07

D

260/246.1, 260/2

C07D 495/04 (2006.01)

Patent

CA 1197506

Abstract There are described 4-phenyl-4,5,6,7-tetrahydro- thieno[2,3-c]pyridines of formula I and the acid addition salts thereof, processes for their preparation them and pharmaceutical compositions containing them. In the new compounds of formula Image (I) R1 represents an amino, acetylamino, hydroxymethyl, methoxymethyl, or Image , group wherein R5 and R6, which may be the same or different, each represent a hydrogen atom alkyl group with 1 to 4 carbon atoms or, R5 and R6 together with the nitrogen atom to which they are attached represent a 5-, 6- or 7-membered ring, any 6-membered ring optionally containing an oxygen atom; R2 and R3, which may be the same or different, represent a hydrogen, fluorine, chlorine or bromine atom or a trifluoromethyl, hydroxy, methoxy, methyl or ethyl group; and R4 represents a straight- or branched-chained alkyl group with 1 to 3 carbon atoms. The new compounds may be used as active substances for compositions for the treatment of depressive states of various origins.

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