Carbapenem antibiotics

Details Carbapenem antibiotics Carbapenem antibiotics

C - Chemistry, Metallurgy

07

D

260/299

C07D 487/04 (2006.01) C07D 477/20 (2006.01)

Patent

CA 1260945

ABSTRACT Disclosed are novel carbapenem derivatives characterized by a 2-substituent of the formula Image wherein A represents C2-C6 straight or branched chain alkylene group and R10 and R11 sach independently represents optionally substituted aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aryl, heterocyclyl, heterocyclyl-aliphatic, heteroaryl or hetero- araliphatic, or R10 and R11 taken together with the S? to which they are attached represent an optionally substituted sulfur- containing heterocyclic ring. Such derivatives are useful as potent antibacterial agents. Also disclosed are processes for the preparation of such derivatives.

491072

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