Fused heterocyclic compounds

Details Fused heterocyclic compounds Fused heterocyclic compounds

C - Chemistry, Metallurgy

07

D

167/207, 260/238

C07D 319/18 (2006.01) C07D 215/06 (2006.01) C07D 215/12 (2006.01) C07D 215/48 (2006.01) C07D 223/16 (2006.01) C07D 241/52 (2006.01) C07D 243/12 (2006.01) C07D 281/10 (2006.01) C07D 311/58 (2006.01) C07D 315/00 (2006.01) C07D 317/54 (2006.01) C07D 317/60 (2006.01) C07D 321/10 (2006.01) C07D 327/04 (2006.01) C07D 327/06 (2006.01) C07D 335/06 (2006.01) C07D 337/08 (2006.01) C07D 339/00 (2006.01) C07D 339/06 (2006.01) C07D 339/08 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1319364

RAN 4060/150 Abstract Compounds of the general formula Image I wherein R1 signifies hydrogen, acyl, lower-alkyl or a group -CHO, -CH2OR10, -COR7 or OR13; R2, R3 and R4 signify hydrogen, lower-alkyl, lower- -alkoxy or halogen; R5 and R6 signify hydrogen or lower-alkyl; R7 signifies hydroxy, lower-alkoxy or NR8R9; R8 and R9 signify hydrogen or lower- -alkyl; X and Y signify >CR14R15, -O-, -S-, >SO, >SO2 or >NR18; R10 and R18 signify hydrogen, lower-alkyl or acyl; M signifies -C(R11)=C(R12)-, -CONH- or -NH-CO-; R11, R12, R14 and R15 signify hydrogen or lower-alkyl, R13 signifies hydrogen, lower-alkyl, which can be substituted by amino, mono-alkylamino, di-alkylamino, morpholino, thiamorpholino or piperazino, or lower-alkoxycarbonyl; and n signifies 1, 2, 3 or 4; with the proviso that at least one of the symbols X and Y comprises a hetero atom and that n is 1, 3 or 4 when X contains a hetero atom, Y represents >C(CH3)2 and R1 represents lower-alkyl or a group -CH2OR10 or -COR7, and salts of compounds of formula I in which R1 represents a carboxy group are useful in the treatment of neoplasias, dermatoses and aging skin.

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